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1.
researchsquare; 2022.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-1336225.v1

ABSTRACT

As the COVID-19 spread over the globe and new variants of COVID-19 keep occurring, reliable real-time forecasts of COVID-19 hospitalizations are critical for public health decision on medical resources allocations such as ICU beds, ventilators, and personnel to prepare for the surge of COVID-19 pandemics. Inspired by the strong association between public search behavior and hospitalization admission, we extended previously-proposed influenza tracking model, ARGO (AutoRegression with GOogle search data), to predict future 2-week national and state-level COVID-19 new hospital admissions. Leveraging the COVID-19 related time series information and Google search data, our method is able to robustly capture new COVID-19 variants’ surges, and self-correct at both national and state level. Based on our retrospective out-of-sample evaluation over 12-month comparison period, our method achieves on average 15% error reduction over the best alternative models collected from COVID-19 forecast hub. Overall, we showed that our method is flexible, self-correcting, robust, accurate, and interpretable, making it a potentially powerful tool to assist health-care officials and decision making for the current and future infectious disease outbreak.


Subject(s)
COVID-19
2.
arxiv; 2022.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2202.02621v1

ABSTRACT

As COVID-19 pandemic progresses, severe flu seasons may happen alongside an increase in cases in cases and death of COVID-19, causing severe burdens on health care resources and public safety. A consequence of a twindemic may be a mixture of two different infections in the same person at the same time, "flurona". Admist the raising trend of "flurona", forecasting both influenza outbreaks and COVID-19 waves in a timely manner is more urgent than ever, as accurate joint real-time tracking of the twindemic aids health organizations and policymakers in adequate preparation and decision making. Under the current pandemic, state-of-art influenza and COVID-19 forecasting models carry valuable domain information but face shortcomings under current complex disease dynamics, such as similarities in symptoms and public healthcare seeking patterns of the two diseases. Inspired by the inner-connection between influenza and COVID-19 activities, we propose ARGOX-Joint-Ensemble which allows us to combine historical influenza and COVID-19 disease forecasting models to a new ensemble framework that handles scenarios where flu and COVID co-exist. Our framework is able to emphasize learning from COVID-related or influenza signals, through a winner-takes-all ensemble fashion. Moreover, our experiments demonstrate that our approach is successful in adapting past influenza forecasting models to the current pandemic, while improving upon previous COVID-19 forecasting models, by steadily outperforming alternative benchmark methods, and remaining competitive with publicly available models.


Subject(s)
COVID-19
3.
arxiv; 2022.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2202.03869v1

ABSTRACT

As the COVID-19 spread over the globe and new variants of COVID-19 keep occurring, reliable real-time forecasts of COVID-19 hospitalizations are critical for public health decision on medical resources allocations such as ICU beds, ventilators, and personnel to prepare for the surge of COVID-19 pandemics. Inspired by the strong association between public search behavior and hospitalization admission, we extended previously-proposed influenza tracking model, ARGO (AutoRegression with GOogle search data), to predict future 2-week national and state-level COVID-19 new hospital admissions. Leveraging the COVID-19 related time series information and Google search data, our method is able to robustly capture new COVID-19 variants' surges, and self-correct at both national and state level. Based on our retrospective out-of-sample evaluation over 12-month comparison period, our method achieves on average 15\% error reduction over the best alternative models collected from COVID-19 forecast hub. Overall, we showed that our method is flexible, self-correcting, robust, accurate, and interpretable, making it a potentially powerful tool to assist health-care officials and decision making for the current and future infectious disease outbreak.


Subject(s)
COVID-19
4.
arxiv; 2021.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2106.12160v2

ABSTRACT

As the COVID-19 ravaging through the globe, accurate forecasts of the disease spread is crucial for situational awareness, resource allocation, and public health decision-making. Alternative to the traditional disease surveillance data collected by the United States (US) Centers for Disease Control and Prevention (CDC), big data from Internet such as online search volumes has been previously shown to contain valuable information for tracking infectious disease dynamics. In this study, we evaluate the feasibility of using Internet search volume of relevant queries to track and predict COVID-19 pandemic. We found strong association between COVID-19 death trend and the search volume of symptom-related queries such as "loss of taste". Then, we further develop an influenza-tracking model to predict future 4-week COVID-19 deaths on the US national level, by combining search volume information with COVID-19 time series information. Encouraged by the 20% error reduction on national level comparing to the baseline time series model, we additionally build state-level COVID-19 deaths models, leveraging the cross-state cross-resolution spatial temporal framework that pools information from search volume and COVID-19 reports across states, regions and the nation. These variants of ARGOX are then aggregated in a winner-takes-all ensemble fashion to produce the final state-level 4-week forecasts. Numerical experiments demonstrate that our method steadily outperforms time series baseline models, and achieves the state-of-the-art performance among the publicly available benchmark models. Overall, we show that disease dynamics and relevant public search behaviors co-evolve during the COVID-19 pandemic, and capturing their dependencies while leveraging historical cases/deaths as well as spatial-temporal cross-region information will enable stable and accurate US national and state-level forecasts.


Subject(s)
COVID-19
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